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MyJove Corporation, Journal of Visualized Experiments, 64, 2012

DOI: 10.3791/4145-v

MyJove Corporation, Journal of Visualized Experiments, 64

DOI: 10.3791/4145

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Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Journal article published in 2012 by Armando Arias ORCID, Luis Ureña, Lucy Thorne, Muhammad A. Yunus, Ian Goodfellow ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Human noroviruses are responsible for most cases of human gastroenteritis (GE) worldwide and are recurrent problem in environments where close person-to-person contact cannot be avoided 1, 2. During the last few years an increase in the incidence of outbreaks in hospitals has been reported, causing significant disruptions to their operational capacity as well as large economic losses. The identification of new antiviral approaches has been limited due to the inability of human noroviruses to complete a productive infection in cell culture 3. The recent isolation of a murine norovirus (MNV), closely related to human norovirus 4 but which can be propagated in cells 5 has opened new avenues for the investigation of these pathogens 6, 7.