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American Chemical Society, Biomacromolecules, 10(13), p. 3039-3045, 2012

DOI: 10.1021/bm3007506

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Detection and Isolation of Dendritic Cells Using Lewis X-functionalized Magnetic Nanoparticles

Journal article published in 2012 by Sara H. Rouhanifard, Ran Xie ORCID, Guoxin Zhang, Xiaoming Sun, Xing Chen, Peng Wu
This paper is available in a repository.
This paper is available in a repository.

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Abstract

DC-specific intracellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) is a receptor found on dendritic cells (DCs) that recognizes antigens bearing mannose-rich or fucosylated glycans, including Lewis X (LeX). Here, we report the fabrication of magnetic nanoparticles coated with multivalent LeX glycans using the Cu (I)-catalyzed azide-alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC detection and enrichment.