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Wiley, Addiction Biology, 3(18), p. 511-522, 2012

DOI: 10.1111/j.1369-1600.2012.00463.x

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Genome-wide association study of a quantitative disordered gambling trait

Journal article published in 2012 by Penelope A. Lind ORCID, Gu Zhu, Grant W. Montgomery, Pamela A. F. Madden, Andrew C. Heath, Nicholas G. Martin, Wendy S. Slutske
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Disordered gambling is a moderately heritable trait, but the underlying genetic basis is largely unknown. We performed a genome-wide association study (GWAS) for disordered gambling using a quantitative factor score in 1,312 twins from 894 Australian families. Association was conducted for 2,381,914 single nucleotide polymorphisms (SNPs) using the family-based association test in Merlin followed by gene and pathway enrichment analyses. Although no SNP reached genome-wide significance, six achieved P-values