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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(46), p. 1974-1976, 2002

DOI: 10.1128/aac.46.6.1974-1976.2002

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Amphotericin B Formulations Exert Additive Antifungal Activity in Combination with Pulmonary Alveolar Macrophages and Polymorphonuclear Leukocytes against Aspergillus fumigatus

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus . DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus .