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Cell Press, American Journal of Human Genetics, 5(82), p. 1202-1210, 2008

DOI: 10.1016/j.ajhg.2008.03.016

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Genetic Analysis of Innate Immunity in Crohn's Disease and Ulcerative Colitis Identifies Two Susceptibility Loci Harboring CARD9 and IL18RAP

Journal article published in 2008 by Alexandra Zhernakova, Eleanora M. Festen, Lude Franke ORCID, Gosia Trynka, Cleo C. van Diemen, Alienke J. Monsuur, Marianna Bevova, Rian M. Nijmeijer, Ruben van ‘t Slot, Roel Heijmans, H. Marike Boezen, David A. van Heel ORCID, Adriaan A. van Bodegraven, Pieter C. F. Stokkers, Cisca Wijmenga ORCID and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The two main phenotypes of inflammatory bowel disease (IBD)—Crohn's disease (CD) and ulcerative colitis (UC)—are chronic intestinal inflammatory disorders with a complex genetic background. Using a three-stage design, we performed a functional candidate-gene analysis of innate immune pathway in IBD. In phase I, we typed 354 SNPs from 85 innate immunity genes in 520 Dutch IBD patients (284 CD, 236 UC) and 808 controls. In phase II, ten autosomal SNPs showing association at p