Published in
Cell Press, American Journal of Human Genetics, 6(82), p. 1231-1240, 2008
DOI: 10.1016/j.ajhg.2008.04.006
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis
Journal article published in 2008 by
Ana M. Valdes,
John Loughlin,
Kirsten M. Timms,
Joyce J. B. van Meurs 
,
Lorraine Southam,
Scott G. Wilson ,
Sally Doherty,
Rik J. Lories ,
Frank P. Luyten,
Alexander Gutin,
Victor Abkevich,
Dongliang Ge,
Albert Hofman,
André G. Uitterlinden,
Deborah J. Hart
and other authors.
,
Lorraine Southam,
Scott G. Wilson ,
Sally Doherty,
Rik J. Lories ,
Frank P. Luyten,
Alexander Gutin,
Victor Abkevich,
Dongliang Ge,
Albert Hofman,
André G. Uitterlinden,
Deborah J. Hart
and other authors.
This paper is available in a repository.
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Abstract
Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p