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MDPI, Marine Drugs, 3(7), p. 435-444, 2009

DOI: 10.3390/md7030435

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Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens

Journal article published in 2009 by Sherif S. Ebada ORCID, Nicole J. de Voogd, Victor Wray, Zhiwei Deng, Wenhan Lin ORCID, Peter Proksch
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 microg/mL.