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Public Library of Science, PLoS ONE, 8(9), p. e104568, 2014

DOI: 10.1371/journal.pone.0104568

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Pleiotropic Functions for Transcription Factor Zscan10

Journal article published in 2014 by Petra Kraus, Sivakamasundari, Sivakamasundari V., Hong Bing Yu, Xing Xing, Siew Lan Lim, Thure Adler, Juan Antonio Aguilar Pimentel, Lore Becker ORCID, J. A. Aguilar-Pimentel, Alexander Bohla, Lillian Garrett ORCID, Wolfgang Hans, Sabine M. Hölter ORCID, Eva Janas and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof.