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Oxford University Press (OUP), The Journal of Infectious Diseases, 1(205), p. 82-86

DOI: 10.1093/infdis/jir708

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HTLV-2 APH-2 Expression Is Correlated With Proviral Load but APH-2 Does Not Promote Lymphocytosis

Journal article published in 2011 by Estelle Douceron, Zhanna Kaidarova, Paola Miyazato, Masao Matsuoka ORCID, Edward L. Murphy, Renaud Mahieux
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We recently discovered the antisense protein of human T-cell leukemia virus (HTLV) type 2 (APH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome. We quantified proviral load, level of tax, and APH-2 in a series of blood samples obtained from a cohort of HTLV-2 carriers. We determined whether APH-2 promotes cell proliferation. APH-2 was detectable in most samples tested and was correlated with proviral load. APH-2 levels were not correlated with lymphocyte count in vivo, consistent with the inability of APH-2 to promote cell proliferation in vitro. APH-2 does not promote cell proliferation and does not cause lymphocytosis.