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Frontiers Media, Frontiers in Physiology, (4)
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Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma
Journal article published in 2013 by
Nobumasa Mizuno,
Yasushi Yatabe 
,
Kazuo Hara,
Susumu Hijioka,
Hiroshi Imaoka ,
Yasuhiro Shimizu,
Shigeru B. H. Ko,
Kenji Yamao
,
Kazuo Hara,
Susumu Hijioka,
Hiroshi Imaoka ,
Yasuhiro Shimizu,
Shigeru B. H. Ko,
Kenji Yamao
This paper is made freely available by the publisher.
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Abstract
Background: CD133 has been identified as a cancer stem cell marker for pancreatic ductal adenocarcinoma. Although leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5), a marker of intestinal stem cells, has been shown to be on a higher level of the stem cell hierarchy than CD133, the expression and function of LGR5 in pancreatic cancer tissue remains unclear. This study investigated tissue expression of LGR5 and CD133 in resected pancreatic cancer tissue.