Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch &amp; Wait Database (IWWD): an international multicentre registry study.

van der Valk, Maxime J. M.; Hilling, Denise E.; Bastiaannet, Esther; Meershoek-Klein Kranenbarg, Elma; Beets, Geerard L.; van de Velde, Cornelis J. H.; Ahlberg, Madeleine; Figueiredo, Nuno L.; Appelt, Ane; Asoglu, Oktar; Habr-Gama, Angelita; Bär, Maria-Theresa; Barroca, Rita; Perez, Rodrigo O.; Beets-Tan, Regina G. H.; Belgers, Eric H. J.; Renehan, Andrew G.; Bosker, Robbert J. I.; Breukink, Stéphanie O.; Bujko, Krysztof; Carvalho, Carlos; Cunningham, Christopher; Creavin, Ben; D'Hoore, André; Gérard, Jean-Pierre; Gollins, Simon; Hoff, Christiaan; Holman, Fabian A.; Hupkens, Britt J. P.; Iseas, Soledad; Jakobsen, Anders; Keshvari, Amir; Koopal, Sietze A.; Kusters, Miranda; Langheinrich, Melanie; Leijtens, Jeroen W. A.; Maas, Monique; Malcomson, Lee; Mamedli, Zamam Z.; Martling, Anna; Matzel, Klaus E.; van der Sluis, Hedwig; Melenhorst, Jarno; Morici, María L.; Murad-Regadas, Sthela M.; O'Dwyer, Sarah T.; Peeters, Koen C. M. J.; Rosa, Isadora; Rossi, Gustavo; Rutten, Harm J. T.; Sanchez Loria, Fernando; van der Sande, Marit E.; São Julião, Guilherme P.; Saunders, Mark; Sun Myint, Arthur; Schiappa, Renaud; Scott, Nigel; Stoot, Jan H. M. B.; Talsma, A. Koen; Terrasson, Isabelle; Tokmak, Handan; Vaccaro, Carlos A.; Vahrmeijer, Alexander L.; Wasowicz, Daria K.; Westreenen, Henderik L.; Winter, Des C.; Wolthuis, Albert M.; Van de Velde, C.; Zimmerman, David D. E.

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Elsevier, The Lancet, 10139(391), p. 2537-2545, 2018

DOI: 10.1016/s0140-6736(18)31078-x

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Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study.

Journal article published in 2018 by Maxime J. M. van der Valk, Denise E. Hilling

, Esther Bastiaannet, Elma Meershoek-Klein Kranenbarg, Geerard L. Beets, Cornelis J. H. van de Velde, Madeleine Ahlberg, Nuno L. Figueiredo, Ane Appelt, Oktar Asoglu, Angelita Habr-Gama, Maria-Theresa Bär, Rita Barroca, Rodrigo O. Perez, Regina G. H. Beets-Tan and other authors.

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Abstract

The strategy of watch and wait (W&W) in patients with rectal cancer who achieve a complete clinical response (cCR) after neoadjuvant therapy is new and offers an opportunity for patients to avoid major resection surgery. However, evidence is based on small-to-moderate sized series from specialist centres. The International Watch & Wait Database (IWWD) aims to describe the outcome of the W&W strategy in a large-scale registry of pooled individual patient data. We report the results of a descriptive analysis after inclusion of more than 1000 patients in the registry.

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