Springer Nature [academic journals on nature.com], British Journal of Cancer, 11(118), p. 1425-1433, 2018
DOI: 10.1038/s41416-018-0082-1
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Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours.