Published in
BioMed Central, Journal of Translational Medicine, 1(16), 2018
DOI: 10.1186/s12967-018-1467-x
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Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade.
Journal article published in 2018 by
Sara Valpione,
Sandro Pasquali,
Luca Giovanni Campana,
Luisa Piccin,
Simone Mocellin,
Jacopo Pigozzo,
Vanna Chiarion-Sileni 
This paper is made freely available by the publisher.
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Abstract
Ipilimumab is a licensed immunotherapy for metastatic melanoma patients and, in the US, as adjuvant treatment for high risk melanoma radically resected. The use of ipilimumab is associated with a typical but unpredictable pattern of side effects. The purpose of this study was to identify clinical features and blood biomarkers capable of predicting ipilimumab related toxicity.