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Elsevier, Clinical Colorectal Cancer, 1(17), p. 80-83

DOI: 10.1016/j.clcc.2017.10.017

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Parallel evaluation of circulating tumor DNA and circulating tumor cells in metastatic colorectal cancer.

Journal article published in 2017 by Giovanni Germano, Gianluca Mauri ORCID, Giulia Siravegna ORCID, Caroline Dive, Jackie Pierce, Federica Di Nicolantonio ORCID, Maurizio D'Incalci, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Tissue biopsy is the gold standard for tumor genotyping, but it is an invasive procedure providing a single snapshot into tumor heterogeneity. Liquid biopsy approaches, encompassing the analysis of circulating tumor DNA (ctDNA) or circulating tumor cells (CTCs), have been proposed as an alternative, with the potential of providing a comprehensive portrait of the tumor molecular landscape. In metastatic colorectal cancer (mCRC), both CTCs and ctDNA analysis have been investigated, but comparative analyses are limited.