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Rockefeller University Press, Journal of Experimental Medicine, 1(215), p. 9-11, 2017

DOI: 10.1084/jem.20172044

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Resolving the dark side of therapy-driven cancer cell death.

Journal article published in 2017 by Eduardo Bonavita, Victoria S. Pelly ORCID, Santiago Zelenay ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.