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F1000 Biology Reports

DOI: 10.3410/b2-37

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PRDM9 sticks its zinc fingers into recombination hotspots and between species

Journal article published in 2010 by Ionel Sandovici ORCID, Carmen Sapienza
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Meiotic recombination events typically cluster within narrow regions of the genome termed hotspots. A series of recent papers reveals that PRDM9, a C2H2-type zinc-finger protein with histone H3 lysine 4 methyltransferase activity, plays a major role in the specification of hotspots. The zinc fingers that contact DNA in a sequence-dependent manner evolve rapidly and are under positive selection, leading to differences in the location of recombination hotspots as well as hybrid sterility.