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American Society of Hematology, Blood, 18(130), p. 2006-2017

DOI: 10.1182/blood-2017-03-775858

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Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia

Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Data provided by SHERPA/RoMEO

Abstract

Key Points ILT3 is ectopically expressed on mature CLL cells and CLL progenitors in the bone marrow. ILT3 controls the activation of Akt kinase in CLL and contributes to a regulatory network defined by a SHIP-1/Deltex1 axis.