目的 探讨在综合ICU镇痛镇静患者护理方面实施每日唤醒疗法护理的方法和效果。方法 选择在ICU进行持续镇痛镇静治疗>24h的患者共90例，实施每日唤醒和相应护理计划并观察记录。结果 实施每日唤醒后，镇痛镇静药物用量减少，机械通气时间减少，与镇静相关的躁动、谵妄事件减少，住ICU时间缩短。结论 ICU镇痛镇静患者实施每日唤醒可有利于其疾病恢复，减少镇静相关不良事件，值得临床关注，但必须加强病情监测和安全护理。 ; Objective: To explore method and effect of daily interruption therapy in the treatment of analgesia and sedation in general ICU. Methods: 90 patients in ICU, who had been treated with continuous analgesia therapy within 24 hours, were selected and would receive daily interruption therapy and corresponding nursing. Results: Analgesic dosage of sedative drugs was reduced, together with mechanical ventilation time, and delirium events associated with calm restless, ICU stay was shortened after the implement of daily interruption therapy and nursing. Conclusion: The application of daily interruption in general ICU is beneficial to their disease recovery, reduce adverse events related with calmness, worthy of clinical attention, but it is imperative to improve the security of condition monitoring and nursing.