Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial

Paton, Nicholas I.; Kityo, Cissy; Thompson, Jennifer; Nankya, Immaculate; Bagenda, Leonard; Hoppe, Anne; Hakim, James; Kambugu, Andrew; van Oosterhout, Joep J.; Kiconco, Mary; Bertagnolio, Silvia; Easterbrook, Philippa J.; Mugyenyi, Peter; Walker, A. Sarah; Agweng, E.; Awio, P.; Bakeinyaga, G.; Isabirye, C.; Kabuga, U.; Kasuswa, S.; Katuramu, M.; Kityo, C.; Kiweewa, F.; Kyomugisha, H.; Lutalo, E.; Mugyenyi, P.; Mulima, D.; Musana, H.; Musitwa, G.; Musiime, V.; Ndigendawan, M.; Namata, H.; Nkalubo, J.; Labejja, P. Ocitti; Okello, P.; Olal, P.; Pimundu, G.; Segonga, P.; Ssali, F.; Tamale, Z.; Tumukunde, D.; Namala, W.; Byaruhanga, R.; Kayiwa, J.; Tukamushaba, J.; Abunyang, S.; Eram, D.; Denis, O.; Lwalanda, R.; Mugarura, L.; Namusanje, J.; Nankya, I.; Ndashimye, E.; Nabulime, E.; Senfuma, O.; Bihabwa, G.; Buluma, E.; Easterbrook, P.; Elbireer, A.; Kambugu, A.; Kamya, D.; Katwere, M.; Kiggundu, R.; Komujuni, C.; Laker, E.; Lubwama, E.; Mambule, I.; Matovu, J.; Nakajubi, A.; Nakku, J.; Nalumenya, R.; Namuyimbwa, L.; Semitala, F.; Wandera, B.; Wanyama, J.; Mugerwa, H.; Lugemwa, A.; Ninsiima, E.; Ssenkindu, T.; Mwebe, S.; Atwine, L.; William, H.; Katemba, C.; Acaku, M.; Ssebutinde, P.; Kitizo, H.; Kukundakwe, J.; Naluguza, M.; Ssegawa, K.; Namayanja,; Nsibuka, F.; Tuhirirwe, P.; Fortunate, M.; Acen, J.; Achidri, J.; Amone, A.; Chamai, M.; Ditai, J.; Kemigisa, M.; Kiconco, M.; Matama, C.; Mbanza, D.; Nambaziira, F.; Odoi, M. Owor; Rweyora, A.; Tumwebaze, G.; Kalanzi, H.; Katabaazi, J.; Kiyingi, A.; Mbidde, M.; Mugenyi, M.; Mwebaze, R.; Okong, P.; Senoga, I.; Abwola, M.; Baliruno, D.; Bwomezi, J.; Kasede, A.; Mudoola, M.; Namisi, R.; Ssennono, F.; Tuhirwe, S.; Abongomera, G.; Amone, G.; Abach, J.; Aciro, I.; Arach, B.; Kidega, P.; Omongin, J.; Ocung, E.; Odong, W.; Philliam, A.; Alima, H.; Ahimbisibwe, B.; Atuhaire, E.; Atukunda, F.; Bekusike, G.; Bulegyeya, A.; Kahatano, D.; Kamukama, S.; Kyoshabire, J.; Nassali, A.; Mbonye, A.; Naturinda, T. M.; Ndukukire,; Nshabohurira, A.; Ntawiha, H.; Rogers, A.; Tibyasa, M.; Kiirya, S.; Atwongyeire, D.; Nankya, A.; Draleku, C.; Nakiboneka, D.; Odoch, D.; Lakidi, L.; Ruganda, R.; Abiriga, R.; Mulindwa, M.; Balmoi, F.; Kafuma, S.; Moriku, E.; Hakim, J.; Reid, A.; Chidziva, E.; Musoro, G.; Warambwa, C.; Tinago, G.; Mutsai, S.; Phiri, M.; Mudzingwa, S.; Bafana, T.; Masore, V.; Moyo, C.; Nhema, R.; Chitongo, S.; Heyderman, Robert; Kabanga, Lucky; Kaunda, Symon; Kudzala, Aubrey; Lifa, Linly; Mallewa, Jane; Moore, Mike; Mtali, Chrissie; Musowa, George; Mwimaniwa, Grace; Sikwese, Rosemary; van Oosterhout, Joep; Ziwoya, Milton; Chimbaka, H.; Chitete, B.; Kamanga, S.; Makwakwa, T. Kayinga E.; Mbiya, R.; Mlenga, M.; Mphande, T.; Mtika, C.; Mushani, G.; Ndhlovu, O.; Ngonga, M.; Nkhana, I.; Nyirenda, R.; Cheruiyot, P.; Kwobah, C.; Ekiru, W. Lokitala; Mokaya, M.; Mudogo, A.; Nzioka, A.; Siika, A.; Tanui, M.; Wachira, S.; Wools-Kaloustian, K.; Alipalli, P.; Chikatula, E.; Kipaila, J.; Kunda, I.; Lakhi, S.; Malama, J.; Mufwambi, W.; Mulenga, L.; Mwaba, P.; Mwamba, E.; Mweemba, A.; Namfukwe, M.; Kerukadho, E.; Ngwatu, B.; Birungi, J.; Paton, N.; Boles, J.; Burke, A.; Castle, L.; Ghuman, S.; Kendall, L.; Hoppe, A.; Tebbs, S.; Thomason, M.; Thompson, J.; Walker, S.; Whittle, J.; Wilkes, H.; Young, N.; Spyer, M.; Kapuya, C.; Kyomuhendo, F.; Kyakundi, D.; Mkandawire, N.; Mulambo, S.; Senyonjo, S.; Angus, B.; Arenas-Pinto, A.; Palfreeman, A.; Post, F.; Ishola, D.; Arribas, J.; Colebunders, R.; Floridia, M.; Giuliano, M.; Mallon, P.; Walsh, P.; De Rosa, M.; Rinaldi, E.; Weller, I.; Gilks, C.; Kangewende, A.; Luyirika, E.; Miiro, F.; Mwamba, P.; Ojoo, S.; Phiri, S.; van Oosterhout, J.; Wapakabulo, A.; Peto, T.; French, N.; Matenga, J.; Cloherty, G.; van Wyk, J.; Norton, M.; Lehrman, S.; Lamba, P.; Malik, K.; Rooney, J.; Snowden, W.; Villacian, J.

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Elsevier, The Lancet HIV, 8(4), p. e341-e348

DOI: 10.1016/s2352-3018(17)30065-6

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Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial

Journal article published in 2017 by Nicholas I. Paton, Cissy Kityo

, Jennifer Thompson, Immaculate Nankya, Leonard Bagenda, Anne Hoppe, James Hakim, Andrew Kambugu, Joep J. van Oosterhout, Mary Kiconco, Silvia Bertagnolio, Philippa J. Easterbrook, Peter Mugyenyi, A. Sarah Walker, E. Agweng and other authors.

This paper is made freely available by the publisher.

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Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial