Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 29(113), p. 8290-8295, 2016
Links
- ORCID
- National Academy of Sciences
- [eprints.gla.ac.uk] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Sleeping Beautyscreen revealsPpargactivation in metastatic prostate cancer
Journal article published in 2016 by
Imran Ahmad,
Ernest Mui,
Laura Galbraith,
Rachana Patel,
Ee Hong Tan,
Mark Salji,
Alistair G. Rust,
Peter Repiscak 
,
Ann Hedley,
Elke Markert,
Carolyn Loveridge,
Louise van der Weyden,
Joanne Edwards,
Owen J. Sansom,
David J. Adams
and other authors.
,
Ann Hedley,
Elke Markert,
Carolyn Loveridge,
Louise van der Weyden,
Joanne Edwards,
Owen J. Sansom,
David J. Adams
and other authors.
This paper is made freely available by the publisher.
Full text: Download
Preprint: archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
SignificanceUsing an unbiased forward mutagenesis screen, we were able to successfully identify candidate genes that drive advanced and metastatic prostate cancer (CaP). Alterations of peroxisome proliferator-activated receptor gamma (PPARG), encoding a regulator crucial of lipid metabolism, appear to play a role in the development of metastatic CaP in both humans and mice.