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National Academy of Sciences, Proceedings of the National Academy of Sciences, 32(113), p. 9075-9080, 2016

DOI: 10.1073/pnas.1524225113

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Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation

Journal article published in 2016 by Kevin A. Link, Shan Lin ORCID, Mahesh Shrestha, Melissa Bowman, Mark Wunderlich, Clara D. Bloomfield, Gang Huang, James C. Mulloy
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance The AE9a protein (alternative splicing at exon 9) is often used to model t(8;21) leukemia. Our study demonstrates that increased oncogene dosage is a critical parameter of AE9a transformation, likely as a result of impaired transcriptional regulation of AML1-ETO target genes. This insight could assist in identifying those downstream genes most critical for t(8;21)-associated transformation.