It is known thatHelicobacter pyloriinfection is associated with chronic gastritis, peptic ulcer, and gastric carcinoma. Due to the increased side effects of the treatment regimens and the development of antimicrobial resistance, a number of natural compounds have been tested as potential alternatives. In this review, we will examine the current knowledge on the effect ofCitrusfruits and their derivatives againstH. pylori, highlighting the remaining outstanding questions on the development of novel therapeutic strategies.