Published in
American Society of Hematology, Blood, 24(127), p. 3040-3053, 2016
DOI: 10.1182/blood-2015-09-671040
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- [europepmc.org] | PDF
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Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms
Journal article published in 2016 by
Anouk Emadali,
Neda Hoghoughi,
Samuel Duley,
Azadeh Hajmirza,
Els Verhoeyen,
Francois-Loic Cosset 
,
Philippe Bertrand,
Christophe Roumier,
Anne Roggy,
Céline Suchaud-Martin,
Martine Chauvet,
Sarah Bertrand,
Sieme Hamaidia,
Sophie Rousseaux ,
Véronique Josserand
and other authors.
,
Philippe Bertrand,
Christophe Roumier,
Anne Roggy,
Céline Suchaud-Martin,
Martine Chauvet,
Sarah Bertrand,
Sieme Hamaidia,
Sophie Rousseaux ,
Véronique Josserand
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points NR3C1 haploinsufficiency is found in patients with a plasmacytoid dendritic cell neoplasm characterized by very poor clinical outcome. Overexpression of lincRNA-3q is a consistent feature of malignant cells in these patients and can be abrogated by BET protein inhibition.