Objective. Assessing the level of anxiety in oncology patients who underwent¹⁸F-FDG PET/CT low dose scan and identifying the main reasons that generate anxiety.Material and Method. The study included 81 cancer patients submitted to the¹⁸F-FDG PET/CT low dose scan. Patients filled in the Scan Experience Questionnaire and the State-Trait Anxiety Inventory (STAI) before and after¹⁸F-FDG PET/CT low dose scan.Results. Substantial levels of anxiety were detected both before and after¹⁸F-FDG PET/CT low dose scan (STAI mean > 30), with a significant increase in the state of anxiety after scan performance (p<0.0001,Medianpre= 31.1, andMedianpos= 33.0).¹⁸F-FDG PET/CT low dose results are the main cause of anxiety both before (79.1%) and after (86.9%) the scan. The information provided by staff both before and on the¹⁸F-FDG PET/CT low dose day was classified mostly as completely understandable (70.5% and 75.3%, resp.) and as very useful (70.5% and 72.6%, resp.) and correlated positively with patients’ overall satisfaction with NM Department (rS=0.372,p=0.004andrS=0.528,p= 0.000, resp.), but not with anxiety levels.Conclusions. Patients perceive high levels of anxiety during the¹⁸F-FDG PET/CT low dose scan and the concern with scan results was pointed out as the main factor for that emotional reaction.