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American Association for the Advancement of Science, Science Translational Medicine, 339(8), 2016

DOI: 10.1126/scitranslmed.aaf2311

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Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

Journal article published in 2016 by Yusuke Shono, Melissa D. Docampo, Jonathan U. Peled, Suelen M. Perobelli, Enrico Velardi, Jennifer J. Tsai, Ann E. Slingerland, Odette M. Smith, Lauren F. Young, Jyotsna Gupta, Sophia R. Lieberman, Hillary V. Jay, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Ke Xu and other authors.
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This paper is available in a repository.

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Abstract

Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated with an increase in graft-versus-host disease in mice and humans.