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Public Library of Science, PLoS ONE, 6(6), p. e20770, 2011

DOI: 10.1371/journal.pone.0020770

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The Role of the Interferon Gamma Release Assay in Assessing Recent Tuberculosis Transmission in a Hospital Incident

Journal article published in 2011 by Louise Bradshaw, Elizabeth Davies, Michael Devine, Peter Flanagan, Paul Kelly, Kevin O'Connor, Francis Drobniewski, Vladislav Nikolayevskyy ORCID, Ibrahim Abubakar
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission.