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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(58), p. 6328-6330, 2014

DOI: 10.1128/aac.03060-14

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Resistome Analysis of Enterobacter cloacae CY01, an Extensively Drug-Resistant Strain Producing VIM-1 Metallo-β-Lactamase from China

Journal article published in 2014 by Ling Yang, Ai-Wu Wu, Dan-Hong Su, Yong-Ping Lin, Ding-Qiang Chen, Yu-Rong Qiu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Resistome analysis of clinical VIM-1-producing Enterobacter cloacae strain CY01 from China revealed the presence of multiple resistance determinants. Two resistance plasmids were identified in CY01. The pCY-VIM plasmid was 14 kb in size and possessed a replicase gene ( repA ), a gene cluster encoding the partitioning function ( parABC ), and a carbapenemase gene ( bla VIM-1 ). Another 5.9-kb plasmid, pCY-MdT, with an aac ( 6 ′)- Ib gene, was very closely related (13 nucleotide differences) to pMdT1, a ColE1 plasmid carrying aac ( 6 ′)- Ib-cr4 .