Dissemin is shutting down on January 1st, 2025

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Elsevier, Current Opinion in Microbiology, 1(12), p. 117-124, 2009

DOI: 10.1016/j.mib.2008.12.001

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Salmonella takes control: effector-driven manipulation of the host

Journal article published in 2009 by Emma J. McGhie, Lyndsey C. Brawn, Peter J. Hume, Daniel Humphreys, Vassilis Koronakis ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and pro-inflammatory responses. This allows Salmonella to invade non-phagocytic epithelial cells, establish and maintain an intracellular replicative niche and, in some cases, disseminate to cause systemic disease. This review focuses on the actions of the effectors on their host cell targets during each stage of Salmonella infection.