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The Company of Biologists, Development, 2016

DOI: 10.1242/dev.126854

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2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration

Journal article published in 2016 by Miguel Tillo ORCID, Camille Charoy ORCID, Quenten Schwarz ORCID, Charlotte H. Maden, Kathryn Davidson, Alessandro Fantin, Christiana Ruhrberg ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The correct migration and axon extension of neurons in the developing nervous system is essential for the appropriate wiring and function of neural networks. Here, we report that O-sulfotransferases, a class of enzymes that modify heparan sulfate proteoglycans (HSPGs), are essential to regulate neuronal migration and axon development. We show that the 6-O-sulfotransferases HS6ST1 and HS6ST2 are essential for cranial axon patterning, whilst the 2-O-sulfotransferase HS2ST is important to regulate the migration of facial branchiomotor (FBM) neurons in the hindbrain. We have also investigated how HS2ST interacts with other signals in the hindbrain and show that FGF signalling regulates FBM neuron migration in an HS2ST-dependent manner.