Published in
American Society of Hematology, Blood, 11(128), p. 1475-1489, 2016
DOI: 10.1182/blood-2016-02-698027
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- American Society of Hematology | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells
Journal article published in 2016 by
Yumeng Mao,
Vincent van Hoef,
Xiaonan Zhang,
Erik Wennerberg 
,
Julie Lorent,
Kristina Witt,
Laia Masvidal,
Shuo Liang ,
Shannon Murray,
Ola Larsson,
Rolf Kiessling,
Andreas Lundqvist
,
Julie Lorent,
Kristina Witt,
Laia Masvidal,
Shuo Liang ,
Shannon Murray,
Ola Larsson,
Rolf Kiessling,
Andreas Lundqvist
This paper is made freely available by the publisher.
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Abstract
Key Points Cytokine-activated NK cells display distinct gene expression programs in response to cytokine withdrawal. IL-15 sustains antitumor functions of NK cells through mTOR-governed metabolic processes.