Published in
American Chemical Society, ACS Medicinal Chemistry Letters, 6(4), p. 538-541, 2013
DOI: 10.1021/ml400039r
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New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi
Journal article published in 2013 by
Laura Friggeri,
Luigi Scipione,
Roberta Costi 
,
Marcel Kaiser,
Francesca Moraca,
Claudio Zamperini,
Bruno Botta ,
Roberto Di Santo ,
Daniela De Vita,
Reto Brun,
Silvano Tortorella
,
Marcel Kaiser,
Francesca Moraca,
Claudio Zamperini,
Bruno Botta ,
Roberto Di Santo ,
Daniela De Vita,
Reto Brun,
Silvano Tortorella
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Abstract
The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1,3-5 showed a potent in vitro antichagasic activity with IC50 values in the low nanomolar concentration range. The (S)-1, (S)-3 and (S)-5 enantiomers showed (an up to) a thousand fold higher activity than the reference drug benznidazole and furthermore low cytotoxicity on rat myogenic L6 cells.