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Antigen-Specific T Cells and Cytokines Detection as Useful Tool for Understanding Immunity against Zoonotic Infections

Journal article published in 2012 by Annalisa Agnone, Alessandra Torina, Gesualdo Vesco, Sara Villari ORCID, Fabrizio Vitale ORCID, Santo Caracappa, Marco Pio La Manna ORCID, Francesco Dieli ORCID, Guido Sireci
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Zoonoses include a broad range of diseases, that are becoming of great interest, due to the climate changing, that cause the adaptation of vectors to new niches and environments. Host immune responses play a crucial role in determining the outcome of infections, as documented by expansion of antigen-specific T cells during several zoonotic infections. Thus, understanding of the contribution of antigen-specific T-cell subsets in the host immune response is a powerful tool to evaluate the different immunological mechanisms involved in zoonotic infections and for the development of effective vaccines. In this paper we discuss the role of T cells in some eukaryotic and prokaryotic infectious models.