Published in
Oxford University Press, Nephrology Dialysis Transplantation, 1(26), p. 170-177, 2010
DOI: 10.1093/ndt/gfq371
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Urinary angiotensinogen reflects the activity of intrarenal renin–angiotensin system in patients with IgA nephropathy
,
Yoshio Konishi,
Naro Ohashi,
Takashi Morikawa,
Maki Urushihara,
Isseki Maeda,
Masahiro Hamada,
Masatsugu Kishida,
Hirofumi Hitomi,
Nobuo Shirahashi,
Hiroyuki Kobori,
Masahito Imanishi
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Abstract
Background. A potential contribution of local activation of the renin–angiotensin system (RAS) to the pathogenesis of renal injury has been indicated by evidence for blood pressure-independent renoprotective effects of angiotensin II (AngII) receptor blockers (ARBs). The present study was performed to test the hypothesis that urinary angiotensinogen provides a specific index of intrarenal RAS status in patients with immunoglobulin A (IgA) nephropathy.