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Oxford University Press, Genetics, 3(195), p. 1173-1176, 2013

DOI: 10.1534/genetics.113.155754

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Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans

Journal article published in 2013 by Iskra Katic ORCID, Helge Großhans
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract We have achieved targeted heritable genome modification in Caenorhabditis elegans by injecting mRNA of the nuclease Cas9 and Cas9 guide RNAs. This system rapidly creates precise genomic changes, including knockouts and transgene-instructed gene conversion.