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SAGE Publications, Multiple Sclerosis Journal, 11(24), p. 1507-1510, 2017

DOI: 10.1177/1352458517739137

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NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

Journal article published in 2017 by Sunny Malhotra, Melissa Sorosina, Jordi Río ORCID, Silvia Peroni, Luciana Midaglia, Luisa M. Villar, José C. Álvarez-Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe K. Zettl, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.