Published in

National Academy of Sciences, Proceedings of the National Academy of Sciences, 31(113), p. 8801-8806, 2016

DOI: 10.1073/pnas.1602978113

Links

Tools

Export citation

Search in Google Scholar

HIF2α–arginase axis is essential for the development of pulmonary hypertension

Journal article published in 2016 by Andrew S. Cowburn, Alexi Crosby, David Macias ORCID, Cristina Branco, Renato D. D. R. Colaço, Mark Southwood, Mark Toshner, Laura E. Crotty Alexander ORCID, Nicholas W. Morrell, Edwin R. Chilvers, Randall S. Johnson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Significance The expression of hypoxia-inducible factor (HIF)-2α in pulmonary endothelium of mice influences pulmonary vascular resistance and development of hypoxic pulmonary hypertension (PH) via an arginase-1–dependent mechanism. The HIF-2α:arginase-1 axis influences the homeostatic regulation of nitric oxide synthesis in the lung. Impaired generation of this vasoactive agent contributes to the initial development and vascular remodeling process of PH.