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National Academy of Sciences, Proceedings of the National Academy of Sciences, 31(113), p. 8801-8806, 2016

DOI: 10.1073/pnas.1602978113

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HIF2α–arginase axis is essential for the development of pulmonary hypertension

Journal article published in 2016 by Andrew S. Cowburn, Alexi Crosby, David Macias ORCID, Cristina Branco, Renato D. D. R. Colaço, Mark Southwood, Mark Toshner, Laura E. Crotty Alexander ORCID, Nicholas W. Morrell, Edwin R. Chilvers, Randall S. Johnson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance The expression of hypoxia-inducible factor (HIF)-2α in pulmonary endothelium of mice influences pulmonary vascular resistance and development of hypoxic pulmonary hypertension (PH) via an arginase-1–dependent mechanism. The HIF-2α:arginase-1 axis influences the homeostatic regulation of nitric oxide synthesis in the lung. Impaired generation of this vasoactive agent contributes to the initial development and vascular remodeling process of PH.