Abstract The synthesis and structure of [Ag(9-methyl-6-furylpurine)(NO₃)] _n are reported. The title compound represents a rare example of a purine derivative metalated at all three endocyclic nitrogen atoms. It forms a two-dimensional coordination polymer comprising 14-membered trinuclear metallacycles. Density functional theory calculations helped to understand the metal-binding behavior of the 6-furylpurine moiety by showing the silver(I)-binding affinities of all three nitrogen donor atoms to be essentially identical under aqueous conditions.