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Karger Publishers, Dementia and Geriatric Cognitive Disorders, 3(30), p. 254-260

DOI: 10.1159/000318744

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Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities

Journal article published in 2010 by Vincent C. T. Mok, Adrian Wong, Winnie C. W. Chu, Yunyun Xiong ORCID, Kelvin S. Wong, Anne Y. Y. Chan, Timothy C. Y. Kwok, Xintao Hu, Ka-Sing Lawrence Wong, W. K. Lee, Wai-Kwong Tang ORCID, Stephen Wong
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

<i>Background/Aims:</i> This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH). <i>Methods:</i> The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms. <i>Results:</i> Seventy-seven stroke patients (mean WMH volume: 39.5 cm<sup>3</sup>) were recruited. Thirty patients (39%) had ≧1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression. <i>Conclusion:</i> Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.