Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients - Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Garrett Zhen-Wei Ng, Philip Sutton, Nancy Wang, Isabelle Ooi, Chayada Thiengtavor, Suthat Fucharoen, Pornthip Chaichompoo, Saovaros Svasti, Odilia Wijburg, Jim Vadolas - Dissemin

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American Society of Hematology, Blood, 23(129), p. 3087-3099, 2017

DOI: 10.1182/blood-2016-07-730135

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Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients

Journal article published in 2017 by Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Garrett Zhen-Wei Ng, Philip Sutton

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, Nancy Wang, Isabelle Ooi, Chayada Thiengtavor, Suthat Fucharoen, Pornthip Chaichompoo, Saovaros Svasti, Odilia Wijburg, Jim Vadolas

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Abstract

Key PointsAberrant neutrophil maturation is associated with reduced effector functions in β-thalassemia. PU.1, the key regulator of terminal neutrophil maturation, is dysregulated in β-thalassemia.