Published in
American Society of Hematology, Blood, 15(129), p. 2132-2142, 2017
DOI: 10.1182/blood-2016-08-730978
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The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity
Journal article published in 2017 by
Laura Oliva,
Ugo Orfanelli,
Massimo Resnati,
Andrea Raimondi 
,
Andrea Orsi,
Enrico Milan,
Giovanni Palladini,
Paolo Milani,
Fulvia Cerruti,
Paolo Cascio,
Simona Casarini,
Paola Rognoni,
Thierry Touvier,
Magda Marcatti,
Fabio Ciceri
and other authors.
,
Andrea Orsi,
Enrico Milan,
Giovanni Palladini,
Paolo Milani,
Fulvia Cerruti,
Paolo Cascio,
Simona Casarini,
Paola Rognoni,
Thierry Touvier,
Magda Marcatti,
Fabio Ciceri
and other authors.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
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Abstract
Key PointsAmyloidogenic PCs show unique PI susceptibility and altered organelle homeostasis, consistent with defective autophagy. Amyloidogenic LC production is an intrinsic cellular stressor that sensitizes to PI toxicity.