Prevalence of sexual dimorphism in mammalian phenotypic traits

Östereicher, Manuela A.; Suzuki, Tomohiro; Karp, Natasha A.; Tamura, Masaru; Yamada, Ikuko; Tanaka, Nobuhiko; Yoshiki, Atsushi; Tolentino, Heather A.; Tolentino, Todd; Vukobradovic, Igor; Shang, Xueyuan; Wang, Yanchun; Zhu, Yingchun; Sohel, Khondoker; Tondat, Sandra; Sleep, Gillian; Teboul, Lydia; Szoke-Kovacs, Zsombor; Stewart, Michelle; Mason, Jeremy; Sinclair, Caroline; Wardle-Jones, Hannah; Woods, Mike; Tudor, Catherine L.; Tuck, Elizabeth J.; Siragher, Emma J.; Vancollie, Valerie E.; Shannon, Carl; Brown, Steve D. M.; Sumowski, Maksymilian T.; Swiatkowska, Agnieszka; Wilson, Heather M.; Vasseur, Laurent; Treise, Irina; Stoeger, Tobias; Benjamini, Yoav; Wurst, Wolfgang; Steinkamp, Ralph; Stoeger, Claudia; Yildrim, AliÖ; Seisenberger, Claudia; Bower, Lynette; Zimmer, Andreas; Wolf, Eckhard; Na, Karp; Obata, Yuichi; Miura, Ikuo; Guo, Shiying; Justice, Monica J.; Schuchbauer, Michael A.; de Angelis, Martin Hrabe; Pedroia, Sheryl M.; Braun, Robert E.; Owen, Celeste; Qu, Dawei; Newbigging, Susan; Al, Beaudet; Morikawa, Lily; Greenaway, Simon; Beaudet, Arthur L.; Kaneda, Hideki; Nutter, Lauryl M. J.; Chesler, Elissa J.; Heller, Ruth; Penton, Patricia; Kobayashi, Kimio; Herault, Yann; Miller, David; Dickinson, Mary E.; Kelsey, Lois; Pereira, Monica; Guo, Ruolin; Flenniken, Ann M.; Kurbatova, Natalja; Law, Napoleon; J., Monica; Fuchs, Helmut; Radage, Adam; Laurin, Valerie; Lelliott, Christopher J.; Mianne, Joffrey; Lan, Qing; Lloyd, K. C. Kent; Hunter, Jane; MacMaster, Suzanne; Gao, Xiang; Gertsenstein, Marina; Mallon, Ann-Marie; Melvin, David G.; Raj, Navis P. S.; Jacob, Elsa; Mank, Judith E.; Loeffler, Jorik; Meehan, Terrence F.; Johnson, Sara; Pearson, Selina A.; Masuya, Hiroshi; Re, Braun; Sanderson, Mark; Mott, Richard F.; Seavitt, John R.; Maritati, Marina; McLaren, Robbie S. B.; McKerlie, Colin; Keskivali-Bond, Piia; Grau, Evelyn; Smedley, Damian; Murray, Stephen A.; Griggs, Nicola; Roberson, Laura-Anne; Kundi, Helen; Pavlovic, Guillaume; Griffiths, Mark N. D.; Sorg, Tania; Parkinson, Helen; Sdm, Brown; Kipp, Christian; Holroyd, Simon A.; Speak, Anneliese O.; Ramirez-Solis, Ramiro; Hooks, Yvette E.; Moreth, Kristin; Green, Angela L.; Kussy, Fiona L.; Santos, Luis; Steel, Karen P.; Neff, Frauke; Maguire, Simon A.; Lafont, David T.; Ej, Chesler; Svenson, Karen L.; Zimprich, Annemarie; Ollert, Markus; Gates, Amy S.; Isherwood, Christopher M.; Mazzeo, Cecilia Icoresi; Lillistone, Charlotte; Maguire, Anna Karin B.; Marie, Wattenhofer-Donze; Jacquot, Sylvie; Me, Dickinson; Schmidt-Weber, Carsten; Le Marchand, Elise; Rathkolb, Birgit; Rozman, Jan; Klopstock, Thomas; Marschall, Susan; Am, Flenniken; Lengger, Christoph; Wakana, Shigeharu; Maier, Holger; Leuchtenberger, Stefanie; Hölter, Sabine M.; Graw, Jochen; Klingenspor, Martin; West, David; Furuse, Tamio; Clary, David A.; Berberovic, Zorana; Wells, Sara; Feugas, Patricia; Eskandarian, Mohammad; Clarke, Shannon; Clark, Greg; Cabezas, Jorge; Westerberg, Henrik; Bubshait, Mohammed; Carroll, Tracy; Danisment, Ozge; Mh, Angelis; Yaacoby, Shay; Creighton, Amie; Clark, James; Fray, Martin; Caulder, Adam; Codner, Gemma; White, Jacqueline K.; Cleak, James; Gardiner, Wendy; Cater, Heather; Brown, Ellen; Doe, Brendan; Gannon, David J.; Galli, Antonella; Cambridge, Emma L.; Caetano, Susana S.; Dabrowska, Monika H.; Estabel, Jeanne; Birling, Marie-Christine; Charles, Philippe; El Amri, Amal; Bekeredjian, Raffi; Calzada-Wack, Julia; Brommage, Robert; Bürger, Antje; Eickelberg, Oliver; Busch, Dirk H.; Gailus-Durner, Valérie; Beckers, Johannes; Guo, S.; Angelis, Martin Hrabe de; Garrett, Lillian; Ayabe, Shinya; Aprile, Joseph Anthony; Allen, Susan; Alcantara, Rafael; Anthony, Lauren F. E.; Ayadi, Abdel; Ali-Hadji, Dalila; André, Philippe; Aguilar-Pimentel, Antonio; Amarie, Oana V.; Becker, Lore; Consortium, Int Mouse Phenotyping; Jk, White

Dissemin
Elissa Chesler`
Östereicher et al., 2017

Published in

Nature Research, Nature Communications, 1(8), 2017

DOI: 10.1038/ncomms15475

Tools

Export citation

Format

@article{Östereicher2017,
  abstract = {AbstractThe role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.},
  author = {Östereicher, Manuela A. and Suzuki, Tomohiro and Karp, Natasha A. and Tamura, Masaru and Yamada, Ikuko and Tanaka, Nobuhiko and Yoshiki, Atsushi and Tolentino, Heather A. and Tolentino, Todd and Vukobradovic, Igor and Shang, Xueyuan and Wang, Yanchun and Zhu, Yingchun and Sohel, Khondoker and Tondat, Sandra and Sleep, Gillian and Teboul, Lydia and Szoke-Kovacs, Zsombor and Stewart, Michelle and Mason, Jeremy and Sinclair, Caroline and Wardle-Jones, Hannah and Woods, Mike and Tudor, Catherine L. and Tuck, Elizabeth J. and Siragher, Emma J. and Vancollie, Valerie E. and Shannon, Carl and Brown, Steve D. M. and Sumowski, Maksymilian T. and Swiatkowska, Agnieszka and Wilson, Heather M. and Vasseur, Laurent and Treise, Irina and Stoeger, Tobias and Benjamini, Yoav and Wurst, Wolfgang and Steinkamp, Ralph and Stoeger, Claudia and Yildrim, AliÖ and Seisenberger, Claudia and Bower, Lynette and Zimmer, Andreas and Wolf, Eckhard and Na, Karp and Obata, Yuichi and Miura, Ikuo and Guo, Shiying and Justice, Monica J. and Schuchbauer, Michael A. and de Angelis, Martin Hrabe and Pedroia, Sheryl M. and Braun, Robert E. and Owen, Celeste and Qu, Dawei and Newbigging, Susan and Al, Beaudet and Morikawa, Lily and Greenaway, Simon and Beaudet, Arthur L. and Kaneda, Hideki and Nutter, Lauryl M. J. and Chesler, Elissa J. and Heller, Ruth and Penton, Patricia and Kobayashi, Kimio and Herault, Yann and Miller, David and Dickinson, Mary E. and Kelsey, Lois and Pereira, Monica and Guo, Ruolin and Flenniken, Ann M. and Kurbatova, Natalja and Law, Napoleon and J., Monica and Fuchs, Helmut and Radage, Adam and Laurin, Valerie and Lelliott, Christopher J. and Mianne, Joffrey and Lan, Qing and Lloyd, K. C. Kent and Hunter, Jane and MacMaster, Suzanne and Gao, Xiang and Gertsenstein, Marina and Mallon, Ann-Marie and Melvin, David G. and Raj, Navis P. S. and Jacob, Elsa and Mank, Judith E. and Loeffler, Jorik and Meehan, Terrence F. and Johnson, Sara and Pearson, Selina A. and Masuya, Hiroshi and Re, Braun and Sanderson, Mark and Mott, Richard F. and Seavitt, John R. and Maritati, Marina and McLaren, Robbie S. B. and McKerlie, Colin and Keskivali-Bond, Piia and Grau, Evelyn and Smedley, Damian and Murray, Stephen A. and Griggs, Nicola and Roberson, Laura-Anne and Kundi, Helen and Pavlovic, Guillaume and Griffiths, Mark N. D. and Sorg, Tania and Parkinson, Helen and Sdm, Brown and Kipp, Christian and Holroyd, Simon A. and Speak, Anneliese O. and Ramirez-Solis, Ramiro and Hooks, Yvette E. and Moreth, Kristin and Green, Angela L. and Kussy, Fiona L. and Santos, Luis and Steel, Karen P. and Neff, Frauke and Maguire, Simon A. and Lafont, David T. and Ej, Chesler and Svenson, Karen L. and Zimprich, Annemarie and Ollert, Markus and Gates, Amy S. and Isherwood, Christopher M. and Mazzeo, Cecilia Icoresi and Lillistone, Charlotte and Maguire, Anna Karin B. and Marie, Wattenhofer-Donze and Jacquot, Sylvie and Me, Dickinson and Schmidt-Weber, Carsten and Le Marchand, Elise and Rathkolb, Birgit and Rozman, Jan and Klopstock, Thomas and Marschall, Susan and Am, Flenniken and Lengger, Christoph and Wakana, Shigeharu and Maier, Holger and Leuchtenberger, Stefanie and Hölter, Sabine M. and Graw, Jochen and Klingenspor, Martin and West, David and Furuse, Tamio and Clary, David A. and Berberovic, Zorana and Wells, Sara and Feugas, Patricia and Eskandarian, Mohammad and Clarke, Shannon and Clark, Greg and Cabezas, Jorge and Westerberg, Henrik and Bubshait, Mohammed and Carroll, Tracy and Danisment, Ozge and Mh, Angelis and Yaacoby, Shay and Creighton, Amie and Clark, James and Fray, Martin and Caulder, Adam and Codner, Gemma and White, Jacqueline K. and Cleak, James and Gardiner, Wendy and Cater, Heather and Brown, Ellen and Doe, Brendan and Gannon, David J. and Galli, Antonella and Cambridge, Emma L. and Caetano, Susana S. and Dabrowska, Monika H. and Estabel, Jeanne and Birling, Marie-Christine and Charles, Philippe and El Amri, Amal and Bekeredjian, Raffi and Calzada-Wack, Julia and Brommage, Robert and Bürger, Antje and Eickelberg, Oliver and Busch, Dirk H. and Gailus-Durner, Valérie and Beckers, Johannes and Guo, S. and Angelis, Martin Hrabe de and Garrett, Lillian and Ayabe, Shinya and Aprile, Joseph Anthony and Allen, Susan and Alcantara, Rafael and Anthony, Lauren F. E. and Ayadi, Abdel and Ali-Hadji, Dalila and André, Philippe and Aguilar-Pimentel, Antonio and Amarie, Oana V. and Becker, Lore and Consortium, Int Mouse Phenotyping and Jk, White},
  doi = {10.1038/ncomms15475},
  journal = {Nature Communications},
  month = {jun},
  title = {Prevalence of sexual dimorphism in mammalian phenotypic traits},
  url = {https://www.nature.com/articles/ncomms15475.pdf},
  volume = {8},
  year = {2017}
}

Download

Export citation

Search in Google Scholar