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American Association for the Advancement of Science, Science, 6292(352), 2016

DOI: 10.1126/science.aad1210

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T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

Journal article published in 2016 by Giuseppina Arbore, Erin E. West, Rosanne Spolski, Avril A. B. Robertson, Andreas Klos, Claudia Rheinheimer, Pavel Dutow, Trent M. Woodruff ORCID, Zu Xi Yu, L. A. ONeill, Luke A. O’Neill, Rebecca C. Coll, Alan Sher, Warren J. Leonard, Jörg Kohl and other authors.
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This paper is available in a repository.

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Abstract

Innate immune crosstalk in T cells The classical view of immune activation is that innate immune cells, such as macrophages and dendritic cells, recognize invading microbes and then alert adaptive immune cells, such as T cells, to respond. Arbore et al. now show that innate and adaptive immunity converge in human and mouse T cells. Activated T cells express components of the complement cascade, which in turn leads to the assembly of NLRP3 inflammasomes—both critical components of innate immunity that help hosts detect and eliminate microbes. In T cells, complement and inflammasomes work together to push T cells to differentiate into a specialized subset of T cells important for eliminating intracellular bacteria. Science , this issue p. 10.1126/science.aad1210