Published in
American Association for the Advancement of Science, Science Translational Medicine, 339(8), 2016
DOI: 10.1126/scitranslmed.aad3099
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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Journal article published in 2016 by
Gabriela Brumatti,
Chunyan Ma,
Najoua Lalaoui,
Nhu-Y. Nguyen,
Mario Navarro,
Elisha de Valle,
Maria C. Tanzer,
Jennifer Richmond,
Natasha Silke,
Margherita Ghisi,
Giovanna Pomilio,
Andrew Wei,
Stefan P. Glaser,
Jessica M. Salmon,
David L. Vaux 
and other authors.
and other authors.
This paper is made freely available by the publisher.
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Abstract
The combination of a SMAC mimetic and a caspase inhibitor kills AML cells by inducing necroptosis.