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Oxford University Press, Metallomics, 9(8), p. 1002-1011, 2016

DOI: 10.1039/c6mt00099a

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Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

Journal article published in 2016 by J. B. Hilton ORCID, A. R. White ORCID, P. J. Crouch ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

It is unclear why ubiquitous expression of mutant SOD1 selectively affects the central nervous system in amyotrophic lateral sclerosis. Here we hypothesise that the central nervous system is primarily affected because, unlike other tissues, it has relatively limited capacity to satiate an increased requirement for Cu.