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National Academy of Sciences, Proceedings of the National Academy of Sciences, 39(113), p. 11022-11027, 2016

DOI: 10.1073/pnas.1604458113

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Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis

Journal article published in 2016 by Nathan Mellor, Leah R. Band ORCID, Aleš Pěnčík, A. Pěňík, Ondřej Novák ORCID, Afaf Rashed, Tara Holman, Michael H. Wilson ORCID, U. Vo, Ute Voß, Anthony Bishopp ORCID, John R. King, Karin Ljung ORCID, Malcolm J. Bennett ORCID, Markus R. Owen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Auxin is a key hormone regulating plant growth and development. We combine experiments and mathematical modeling to reveal how auxin levels are maintained via feedback regulation of genes encoding key metabolic enzymes. We describe how regulation of auxin oxidation via transcriptional control of Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1 ( AtDAO1 ) expression is important at low to normal auxin concentrations. In contrast, higher auxin levels lead to increased Gretchen Hagen3 expression and auxin conjugation. Integrating this understanding into a multicellular model of root auxin dynamics successfully predicts that the dao1-1 mutant has an auxin-dependent longer root hair phenotype. Our findings reveal the importance of auxin homeostasis to maintain this hormone at optimal levels for plant growth and development.