The use of apps/games in healthcare interventions is gaining popularity, but there is still a gap in the understanding on how these types of interventions are used for the management of Parkinson disease (PD). In fact, gamification in healthcare (mHealth) can help people initiate healthier activities in various areas, such as losing weight, sleeping more, making healthier food choices, improving fitness, and monitoring health metrics. In this vein, there are six key elements that can help to understanding the concept of gamification, namely: i) perception of play; ii) clear rules; iii) concrete objectives and intermediate goals; iv) group dynamics; v) motivation with rewards; and vi) continuing the challenge (Marcus, 2013). Motivated by the above perspectives, and targeting intelligent early detection and intervention in PD area, we intend to explore here the Personalized Game Suite (PGS) approach, as part of the H2020 i-Prognosis project (www.i-prognosis.eu), that introduces for the first time the integration of different serious game (i.e., ExerGames, DietaryGames, EmoGames and Hand writing/Voice (H/V) Games) in a unified platform. The use of apps/games in healthcare interventions is gaining popularity, but there is still a gap in the understanding on how these types of interventions are used for the management of Parkinson disease (PD). In fact, gamification in healthcare (mHealth) can help people initiate healthier activities in various areas, such as losing weight, sleeping more, making healthier food choices, improving fitness, and monitoring health metrics. In this vein, there are six key elements that can help to understanding the concept of gamification, namely: i) perception of play; ii) clear rules; iii) concrete objectives and intermediate goals; iv) group dynamics; v) motivation with rewards; and vi) continuing the challenge (Marcus, 2013). Motivated by the above perspectives, and targeting intelligent early detection and intervention in PD area, we intend to explore here the Personalized Game Suite (PGS) approach, as part of the H2020 i-Prognosis project (www.i-prognosis.eu), that introduces for the first time the integration of different serious game (i.e., ExerGames, DietaryGames, EmoGames and Hand writing/Voice (H/V) Games) in a unified platform.