Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Zhao, Z. (Zhiguo); Wen, W. (Wanqing); Michailidou, K. (Kyriaki); Wang, Q. (Qing); Zhang, B. (Bin); Bolla, Manjeet K. (Manjeet); Long, J. (Jirong); Shu, X.-O. (Xiao-Ou); Schmidt, Marjanka K. (Marjanka); Milne, Roger L. (Roger); García-Closas, M. (Montserrat); Lindstrom, S. (Stephen); Czene, K. (Kamila); Dörk, T. (Thilo); Dumont, M. (Martine); Bojesen, Stig E. (Stig); Flesch-Janys, D. (Dieter); Fletcher, O. (Olivia); Andrulis, Irene L. (Irene); Flyger, H. (Henrik); Fostira, F. (Florentia); Gammon, M. (Marilie); Beckmann, Matthias W. (Matthias); Guénel, P. (Pascal); Hamann, U. (Ute); Harrington, P. (Patricia); Bogdanova, Natalia V. (Natalia); Børresen-Dale, Anne-Lise; Brand, Judith S. (Judith S.); Hartman, J. M. (Joost); Jakubowska, A. (Anna); Jasmine, F. (Farzana); Johnson, N. (Nichola); Kabisch, M. (Maria); Khan, S. (Sofia); Couch, Fergus J. (Fergus); Cross, Simon S. (Simon); Kosma, V.-M. (Veli-Matti); Kriege, M. (Mieke); Kristensen, V. (Vessela); Fasching, Peter A. (Peter); Figueroa, Jonine D. (Jonine); Le Marchand, L. (Loic); Lee, E. (Eunjung); Li, J. (Jingmei); Lindblom, A. (Annika); Giles, Graham G. (Graham); Lophatananon, A. (Artitaya); Haiman, Christopher A. (Christopher A.); Lubinski, J. (Jan); Mannermaa, A. (Arto); Manoukian, S. (Siranoush); Hooning, Maartje J. (Maartje); Hopper, John L. (John); Margolin, S. (Sara); Marme, F. (Federick); John, Esther M. (Esther); Meijers-Heijboer, E. J. (Hanne); Meindl, A. (Alfons); Miao, X.; Nevanlinna, H. (Heli); Kibriya, Muhammad G. (Muhammad); Knight, Julia A. (Julia A.); Neven, P. (Patrick); Perkins, B. (Barbara); Peterlongo, P. (Paolo); Phillips, K.-A. (Kelly-Anne); Pykäs, K. (Katri); Rudolph, A. (Anja); Santella, R. (Regina); Schoemaker, M. (Minouk); Luben, Robert N. (Robert); Shah, M. (Mitul); Malone, Kathleen E. (Kathleen E.); Shrubsole, M. (Martha); Tomlinson, I. (Ian); Meijers-Heijboer, Hanne; Torres, D. (Diana); McLean, Catriona A. (Catriona Ann); Truong, T. (Thérèse); Ursin, G. (Giske); Luijt, R. B. (Rob) van der; Miao, Hui; Muir, Kenneth R. (K.); Neuhausen, Susan L. (Susan); Wang-Gohrke, S. (Shan); Winqvist, R. (Robert); Olson, Janet E. (Janet); Zamora, M. P. (Pilar); Zhao, H. (Hui); Simard, J. (Jacques); Pylkäs, Katri; Hall, P. (Per); Kraft, P. (Peter); Sawyer, Elinor J. (Elinor); Schmutzler, Rita K. (Rita); Hunter, D. (David); Zheng, W. (Wei); Chang-Claude, J. (Jenny); Southey, Melissa C. (Melissa); Swerdlow, Anthony J. (Anthony ); Ahsan, H. (Habibul); Toland, Amanda E. (Amanda); Aittomäki, K. (Kristiina); Anton-Culver, H. (Hoda); Arndt, V. (Volker); Beeghly-Fadiel, A. (Alicia); Van Der Luijt, Rob B.; Verhoef, Senno; Benítez, J. (Javier); Whittemore, Alice S. (Alice S.); Blomqvist, C. (Carl); Pilar Zamora, M.; Borresen-Dale, A.-L. (Anne-Lise); Dunning, Alison M. (Alison); Brauch, H. (Hiltrud); Brenner, H. (Hermann); Burwinkel, B. (Barbara); Pharoah, Paul D. P. (Paul); Cai, Q. (Qiuyin); Easton, Douglas F. (Douglas F.); Casey, G. (Graham); Chenevix-Trench, G. (Georgia); Cox, A. (Angela)

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Marjanka Schmidt
Zhao et al., 2016

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Springer, Cancer Causes and Control, 5(27), p. 679-693, 2016

DOI: 10.1007/s10552-016-0741-6

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@article{Zhao2016,
  abstract = {Purpose: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. Methods: We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies. Results: The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p },
  author = {Zhao, Z. (Zhiguo) and Wen, W. (Wanqing) and Michailidou, K. (Kyriaki) and Wang, Q. (Qing) and Zhang, B. (Bin) and Bolla, Manjeet K. (Manjeet) and Long, J. (Jirong) and Shu, X.-O. (Xiao-Ou) and Schmidt, Marjanka K. (Marjanka) and Milne, Roger L. (Roger) and García-Closas, M. (Montserrat) and Lindstrom, S. (Stephen) and Czene, K. (Kamila) and Dörk, T. (Thilo) and Dumont, M. (Martine) and Bojesen, Stig E. (Stig) and Flesch-Janys, D. (Dieter) and Fletcher, O. (Olivia) and Andrulis, Irene L. (Irene) and Flyger, H. (Henrik) and Fostira, F. (Florentia) and Gammon, M. (Marilie) and Beckmann, Matthias W. (Matthias) and Guénel, P. (Pascal) and Hamann, U. (Ute) and Harrington, P. (Patricia) and Bogdanova, Natalia V. (Natalia) and Børresen-Dale, Anne-Lise and Brand, Judith S. (Judith S.) and Hartman, J. M. (Joost) and Jakubowska, A. (Anna) and Jasmine, F. (Farzana) and Johnson, N. (Nichola) and Kabisch, M. (Maria) and Khan, S. (Sofia) and Couch, Fergus J. (Fergus) and Cross, Simon S. (Simon) and Kosma, V.-M. (Veli-Matti) and Kriege, M. (Mieke) and Kristensen, V. (Vessela) and Fasching, Peter A. (Peter) and Figueroa, Jonine D. (Jonine) and Le Marchand, L. (Loic) and Lee, E. (Eunjung) and Li, J. (Jingmei) and Lindblom, A. (Annika) and Giles, Graham G. (Graham) and Lophatananon, A. (Artitaya) and Haiman, Christopher A. (Christopher A.) and Lubinski, J. (Jan) and Mannermaa, A. (Arto) and Manoukian, S. (Siranoush) and Hooning, Maartje J. (Maartje) and Hopper, John L. (John) and Margolin, S. (Sara) and Marme, F. (Federick) and John, Esther M. (Esther) and Meijers-Heijboer, E. J. (Hanne) and Meindl, A. (Alfons) and Miao, X. and Nevanlinna, H. (Heli) and Kibriya, Muhammad G. (Muhammad) and Knight, Julia A. (Julia A.) and Neven, P. (Patrick) and Perkins, B. (Barbara) and Peterlongo, P. (Paolo) and Phillips, K.-A. (Kelly-Anne) and Pykäs, K. (Katri) and Rudolph, A. (Anja) and Santella, R. (Regina) and Schoemaker, M. (Minouk) and Luben, Robert N. (Robert) and Shah, M. (Mitul) and Malone, Kathleen E. (Kathleen E.) and Shrubsole, M. (Martha) and Tomlinson, I. (Ian) and Meijers-Heijboer, Hanne and Torres, D. (Diana) and McLean, Catriona A. (Catriona Ann) and Truong, T. (Thérèse) and Ursin, G. (Giske) and Luijt, R. B. (Rob) van der and Miao, Hui and Muir, Kenneth R. (K.) and Neuhausen, Susan L. (Susan) and Wang-Gohrke, S. (Shan) and Winqvist, R. (Robert) and Olson, Janet E. (Janet) and Zamora, M. P. (Pilar) and Zhao, H. (Hui) and Simard, J. (Jacques) and Pylkäs, Katri and Hall, P. (Per) and Kraft, P. (Peter) and Sawyer, Elinor J. (Elinor) and Schmutzler, Rita K. (Rita) and Hunter, D. (David) and Zheng, W. (Wei) and Chang-Claude, J. (Jenny) and Southey, Melissa C. (Melissa) and Swerdlow, Anthony J. (Anthony ) and Ahsan, H. (Habibul) and Toland, Amanda E. (Amanda) and Aittomäki, K. (Kristiina) and Anton-Culver, H. (Hoda) and Arndt, V. (Volker) and Beeghly-Fadiel, A. (Alicia) and Van Der Luijt, Rob B. and Verhoef, Senno and Benítez, J. (Javier) and Whittemore, Alice S. (Alice S.) and Blomqvist, C. (Carl) and Pilar Zamora, M. and Borresen-Dale, A.-L. (Anne-Lise) and Dunning, Alison M. (Alison) and Brauch, H. (Hiltrud) and Brenner, H. (Hermann) and Burwinkel, B. (Barbara) and Pharoah, Paul D. P. (Paul) and Cai, Q. (Qiuyin) and Easton, Douglas F. (Douglas F.) and Casey, G. (Graham) and Chenevix-Trench, G. (Georgia) and Cox, A. (Angela)},
  doi = {10.1007/s10552-016-0741-6},
  journal = {Cancer Causes and Control},
  month = {apr},
  pages = {679-693},
  title = {Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry},
  url = {http://link.springer.com/content/pdf/10.1007/s10552-016-0741-6.pdf},
  volume = {27},
  year = {2016}
}

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Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Journal article published in 2016 by Z. (Zhiguo) Zhao, W. (Wanqing) Wen, K. (Kyriaki) Michailidou, Q. (Qing) Wang, B. (Bin) Zhang, Manjeet K. (Manjeet) Bolla, J. (Jirong) Long, X.-O. (Xiao-Ou) Shu, Marjanka K. (Marjanka) Schmidt

, Roger L. (Roger) Milne, M. (Montserrat) García-Closas, S. (Stephen) Lindstrom, K. (Kamila) Czene, T. (Thilo) Dörk, M. (Martine) Dumont and other authors. Z. (Zhiguo) Zhao, W. (Wanqing) Wen, K. (Kyriaki) Michailidou, Q. (Qing) Wang, B. (Bin) Zhang, Manjeet K. (Manjeet) Bolla, J. (Jirong) Long, X.-O. (Xiao-Ou) Shu, Marjanka K. (Marjanka) Schmidt

, Roger L. (Roger) Milne, M. (Montserrat) García-Closas, S. (Stephen) Lindstrom, K. (Kamila) Czene, T. (Thilo) Dörk, M. (Martine) Dumont, Stig E. (Stig) Bojesen, D. (Dieter) Flesch-Janys, O. (Olivia) Fletcher, Irene L. (Irene) Andrulis, H. (Henrik) Flyger, F. (Florentia) Fostira, M. (Marilie) Gammon, Matthias W. (Matthias) Beckmann, P. (Pascal) Guénel, U. (Ute) Hamann, P. (Patricia) Harrington, Natalia V. (Natalia) Bogdanova, Anne-Lise Børresen-Dale, Judith S. (Judith S.) Brand

, J. M. (Joost) Hartman

, A. (Anna) Jakubowska, F. (Farzana) Jasmine, N. (Nichola) Johnson, M. (Maria) Kabisch, S. (Sofia) Khan

, Fergus J. (Fergus) Couch, Simon S. (Simon) Cross, V.-M. (Veli-Matti) Kosma, M. (Mieke) Kriege, V. (Vessela) Kristensen, Peter A. (Peter) Fasching, Jonine D. (Jonine) Figueroa, L. (Loic) Le Marchand, E. (Eunjung) Lee, J. (Jingmei) Li, A. (Annika) Lindblom, Graham G. (Graham) Giles

, A. (Artitaya) Lophatananon, Christopher A. (Christopher A.) Haiman, J. (Jan) Lubinski, A. (Arto) Mannermaa, S. (Siranoush) Manoukian

, Maartje J. (Maartje) Hooning, John L. (John) Hopper, S. (Sara) Margolin, F. (Federick) Marme, Esther M. (Esther) John, E. J. (Hanne) Meijers-Heijboer, A. (Alfons) Meindl, X. Miao, H. (Heli) Nevanlinna, Muhammad G. (Muhammad) Kibriya, Julia A. (Julia A.) Knight, P. (Patrick) Neven, B. (Barbara) Perkins, P. (Paolo) Peterlongo, K.-A. (Kelly-Anne) Phillips, K. (Katri) Pykäs, A. (Anja) Rudolph, R. (Regina) Santella, M. (Minouk) Schoemaker, Robert N. (Robert) Luben

, M. (Mitul) Shah, Kathleen E. (Kathleen E.) Malone, M. (Martha) Shrubsole, I. (Ian) Tomlinson, Hanne Meijers-Heijboer, D. (Diana) Torres

, Catriona A. (Catriona Ann) McLean, T. (Thérèse) Truong, G. (Giske) Ursin, R. B. (Rob) van der Luijt, Hui Miao, Kenneth R. (K.) Muir, Susan L. (Susan) Neuhausen, S. (Shan) Wang-Gohrke, R. (Robert) Winqvist, Janet E. (Janet) Olson, M. P. (Pilar) Zamora, H. (Hui) Zhao, J. (Jacques) Simard, Katri Pylkäs, P. (Per) Hall, P. (Peter) Kraft, Elinor J. (Elinor) Sawyer, Rita K. (Rita) Schmutzler, D. (David) Hunter, W. (Wei) Zheng, J. (Jenny) Chang-Claude, Melissa C. (Melissa) Southey, Anthony J. (Anthony ) Swerdlow, H. (Habibul) Ahsan, Amanda E. (Amanda) Toland, K. (Kristiina) Aittomäki, H. (Hoda) Anton-Culver, V. (Volker) Arndt, A. (Alicia) Beeghly-Fadiel, Rob B. Van Der Luijt, Senno Verhoef, J. (Javier) Benítez, Alice S. (Alice S.) Whittemore, C. (Carl) Blomqvist, M. Pilar Zamora, A.-L. (Anne-Lise) Borresen-Dale, Alison M. (Alison) Dunning

, H. (Hiltrud) Brauch, H. (Hermann) Brenner, B. (Barbara) Burwinkel, Paul D. P. (Paul) Pharoah, Q. (Qiuyin) Cai, Douglas F. (Douglas F.) Easton, G. (Graham) Casey, G. (Georgia) Chenevix-Trench, A. (Angela) Cox

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Abstract

Purpose: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. Methods: We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies. Results: The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p

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Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry

Abstract