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National Academy of Sciences, Proceedings of the National Academy of Sciences, 42(110), p. 16963-16968, 2013

DOI: 10.1073/pnas.1309839110

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Loss of metabotropic glutamate receptor 2 escalates alcohol consumption

Journal article published in 2013 by Zhifeng Zhou, Camilla Karlsson, Tiebing Liang, Wei Xiong, Mitsuru Kimura, Jenica D. Tapocik, Qiaoping Yuan, Estelle Barbier, Austin Feng, Meghan Flanigan, Eric Augier, Mary-Anne Enoch, Colin A. Hodgkinson ORCID, Pei-Hong Shen, David M. Lovinger and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Gene identification for complex behavioral traits, alcoholism in particular, has been largely unsuccessful, in part because of the rarity of many causative variants and the heterogeneity and small effect size of the causal loci. Artificially selected animals may be valuable in gene identification. We identified a causal role of metabotropic glutamate receptor 2 (mGluR2) in altered alcohol preference via genomic sequencing of selectively bred rats, linkage analysis in the F2 rats, and function validation in mGluR2 null mice. Our findings represent a valuable contribution to understanding the neurobiology of alcoholism and a strategy for gene identification for complex behavior traits.