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MDPI, Marine Drugs, 12(12), p. 6014-6027, 2014

DOI: 10.3390/md12126014

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Nano- and Microdelivery Systems for Marine Bioactive Lipids

Journal article published in 2014 by David M. Pereira ORCID, Patrícia Valentão, Paula B. Andrade
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

There is an increasing body of evidence of the positive impact of several marine lipids on human health. These compounds, which include ω-3 polyunsaturated fatty acids, have been shown to improve blood lipid profiles and exert anti-inflammatory and cardioprotective effects. The high instability of these compounds to oxidative deterioration and their hydrophobicity have a drastic impact in their pharmacokinetics. Thus, the bioavailability of these compounds may be affected, resulting in their inability to reach the target sites at effective concentrations. In this regard; micro/nanoparticles can offer a wide range of solutions that can prevent the degradation of targeted molecules, increase their absorption, uptake and bioavailability. In this work we will present the options currently available concerning micro- and nanodelivery systems for marine lipids; with emphasis on micro/nanoparticles; such as micro/nanocapsules and emulsions. A wide range of bottom-up approaches using casein, chitosan, cyclodextrins, among others; will be discussed.